Cover Picture: Chemical Approaches to the Development of Artificial Transcription Factors Based on Pyrrole‐Imidazole Polyamides (Chem. Rec. 6/2021)
نویسندگان
چکیده
The cover picture shows a DNA recognition system that imitates the dimer formation of natural transcription factor pairs. Pyrrole-imidazole polyamides bind to programmable sequences and enable us target specific genomic regions. We have developed artificial factors by expanding function pyrrole-imidazole with other compounds (e.g., peptides epigenetic modulators), achieving gene regulation chemicals based on sequence information. See Personal Account T. Hidaka H. Sugiyama (DOI:10.1002/tcr.202000158).
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ژورنال
عنوان ژورنال: Chemical Record
سال: 2021
ISSN: ['1527-8999', '1528-0691']
DOI: https://doi.org/10.1002/tcr.202180601